Prof. Bernhard Lämmle

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Prof. Lämmle war bis zu seinem altersbedingten Rücktritt Ende Juli 2013 Direktor und Chefarzt der Universitätsklinik für Hämatologie und des Hämatologischen Zentrallabors des Inselspitals und der Universität Bern sowie ordentlicher Professor für Hämatologie. Seit Herbst 2013 ist er als Senior Professor am CTH der Universitätsmedizin Mainz tätig. Sein breites wissenschaftliches Interesse betrifft zahlreiche klinische, labordiagnostische und grundlagenwissenschaftliche Fragen der Hämatologie, Hämostase und Thrombose mit einem Schwerpunkt auf dem Gebiet der thrombotischen Mikroangiopathien, insbesondere der thrombotisch thrombozytopenischen Purpura und der Metalloprotease ADAMTS13. Bernhard Lämmle ist Autor von über 280 Publikationen und hat zahlreiche State-of-the-Art, Educational und Plenary Lectures an internationalen Kongressen gehalten. Im Juli 2017 wurde ihm von der International Society on Thrombosis and Hemostasis (ISTH) der Distinguished Career Award verliehen. In Mainz unterstützt er bestehende Forschungsgruppen und ist in der Nachwuchsförderung aktiv.

Prof. Lämmle ist gemeinsam mit Dr. von Auer (Med. III) Leiter des Translationalen Forschungsprojekts 'Thrombotische thrombozytopenische Purpura'

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Originalarbeiten

• Constantinescu-Bercu A, McCann S, Dragunaite B, Sivera R, Tan Y, Keogh L, Vanhoorelbeke K, Rossmann H, Lämmle B, de Groot R, Scully M. A microfluidic approach reveals ongoing disease activity in thrombotic thrombocytopenic purpura patients despite clinical remission. J Thromb Haemost. 2025 Oct;23(10):3185-3197.
• Coppo P, Bubenheim M, Benhamou Y, Völker L, Brinkkötter P, Kühne L, Knöbl P, Mingot-Castellano ME, Pascual-Izquierdo C, de la Rubia J, Del Rio Garma J, Chaturvedi S, Masias C, Mazepa M, Zheng XL, Sinkovits G, Réti M, Patriquin CJ, Pavenski K, Boechat T, Farias J, Oliveira Ribeiro EF, Lobo de Andrade ML, Veyradier A, Joly B, Bouzid R, Sakai K, Matsumoto M, Agosti P, Mancini I, Peyvandi F, Gavriilaki E, Stubbs M, Hmaid A, Cataland S, Lämmle B, Scully M. Caplacizumab use in immune-mediated thrombotic thrombocytopenic purpura: an international multicentre retrospective Cohort study (The Capla 1000+ project). EClinicalMedicine. 2025 Mar 30;82:103168.
• De Waele L, Sakai K, Mancini I, Sinkovits G, Falter T, Inoue T, Agosti P, Rossmann H, Von Auer C, Tersteeg C, De Meyer SF, Joly BS, Veyradier A, Coppo P, Fijnheer R, Peyvandi F, Prohászka Z, Lämmle B, Vanhoorelbeke K. Open ADAMTS-13 conformation index predicts earlier relapse in immune-mediated thrombotic thrombocytopenic purpura. J Thromb Haemost. 2024 Feb;22(2):493-502.
• Häuser F, Rossmann H, Adenaeuer A, Shrestha A, Marandiuc D, Paret C, Faber J, Lackner KJ, Lämmle B, Beck O. Hereditary Spherocytosis: Can Next-Generation Sequencing of the Five Most Frequently Affected Genes Replace Time-Consuming Functional Investigations? Int J Mol Sci. 2023 Nov 30;24(23):17021.
• Falter T, Rossmann H, de Waele L, Dekimpe C, von Auer C, Müller-Calleja N, Häuser F, Degreif A, Marandiuc D, Messmer X, Sprinzl M, Lackner KJ, Jurk K, Vanhoorelbeke K, Lämmle B. A novel von Willebrand factor multimer ratio as marker of disease activity in thrombotic thrombocytopenic purpura. Blood Adv. 2023 Sep 12;7(17):5091-5102.
• Adenaeuer A, Barco S, Trinchero A, Krutmann S, Nazir HF, Ambaglio C, Rocco V, Pancione Y, Tomao L, Ruiz-Sáez A, Echenagucia M, Alesci S, Sollfrank S, Ezigbo ED, Häuser F, Lackner KJ, Lämmle B*, Rossmann H*. Severe high-molecular-weight kininogen deficiency: clinical characteristics, deficiency-causing KNG1 variants, and estimated prevalence. J Thromb Haemost. 2023 Feb;21(2):237-254. *Shared last authorship
• Méan M, Breakey N, Stalder O, Alberio L, Limacher A, Angelillo-Scherrer A, Fontana P, Beer HJ, Rodondi N, Aujesky D, Lämmle B, Escher R. Thrombophilia and outcomes of venous thromboembolism in older patients. Res Pract Thromb Haemost. 2022 Dec 16;7(1):100015.
• Tarasco E, von Krogh AS, Hrdlickova R, Braschler TR, Iwaniec T, Knöbl PN, Hamada E, Pikovsky O, Farese S, Gutwein O, Kessler P, Schultz NH, von Auer C, Windyga J, Friedman K, Hrachovinova I, George JN, Matsumoto M, Schneppenheim R, Lämmle B, Kremer Hovinga JA. Hereditary thrombotic thrombocytopenic purpura and COVID-19: Impacts of vaccination and infection in this rare disease. Res Pract Thromb Haemost. 2022 Oct 21;6(7):e12814.
• Kangro K, Roose E, Joly BS, Sinkovits G, Falter T, von Auer C, Rossmann H, Reti M, Voorberg J, Prohászka Z, Lämmle B, Coppo P, Veyradier A, De Meyer SF, Männik A, Vanhoorelbeke K. Anti-ADAMTS13 autoantibody profiling in patients with immune-mediated thrombotic thrombocytopenic purpura. Blood Adv. 2021 Sep 14;5(17):3427-343.
• Falter T, Rossmann H, Menge P, Goetje J, Groenwoldt S, Weinmann A, Sivanathan V, Schulz A, Lemmermann NAW, Danckwardt S, Lackner KJ, Galle PR, Scharrer I, Lämmle B, Sprinzl MF. No Evidence for Classic Thrombotic Microangiopathy in COVID-19. J Clin Med. 2021 Feb 9;10(4):671.
• Wendt R, Kalbitz S, Otto F, Falter T, Beige J, Rossmann H, Lämmle B. Diagnosis of Hereditary TTP Caused by Homozygosity for a Rare Complex ADAMTS13 Allele After Salmonella Infection in a 43-Year-Old Asylum Seeker. Front Med (Lausanne). 2021 Feb 26;8:639441.
• Alwan F, Vendramin C, Budde U, Liesner R, Taylor A, Thomas M, Lämmle B, Scully M. Assessing thrombogenesis and treatment response in congenital thrombotic thrombocytopenic purpura. EJHaem. 2021 Feb 28;2(2):188-195.
• Tarasco E, Bütikofer L, Friedman KD, George JN, Hrachovinova I, Knöbl PN, Matsumoto M, von Krogh AS, Aebi-Huber I, Cermakova Z, Górska-Kosicka M, Jalowiec KA, Largiadèr CR, Prohászka Z, Sinkovits G, Windyga J, Lämmle B, Kremer Hovinga JA. Annual incidence and severity of acute episodes in hereditary thrombotic thrombocytopenic purpura. Blood. 2021 Jun 24;137(25):3563-3575.
• Cuker A, Cataland SR, Coppo P, de la Rubia J, Friedman KD, George JN, Knoebl PN, Kremer Hovinga JA, Lämmle B, Matsumoto M, Pavenski K, Peyvandi F, Sakai K, Sarode R, Thomas MR, Tomiyama Y, Veyradier A, Westwood JP, Scully M. Redefining outcomes in immune TTP: an international working group consensus report. Blood. 2021 Apr 8;137(14):1855-1861.
• Falter T, Böschen S, Schepers M, Beutel M, Lackner K, Scharrer I, Lämmle B. Influence of Personality, Resilience and Life Conditions on Depression and Anxiety in 104 Patients Having Survived Acute Autoimmune Thrombotic Thrombocytopenic Purpura. J Clin Med. 2021 Jan 19;10(2):365.
• Velásquez Pereira LC, Roose E, Graça NAG, Sinkovits G, Kangro K, Joly BS, Tellier E, Kaplanski G, Falter T, Von Auer C, Rossmann H, Feys HB, Reti M, Prohászka Z, Lämmle B, Voorberg J, Coppo P, Veyradier A, De Meyer SF, Männik A, Vanhoorelbeke K. Immunogenic hotspots in the spacer domain of ADAMTS13 in immune-mediated thrombotic thrombocytopenic purpura. J Thromb Haemost. 2021 Feb;19(2):478-488.
• Adenaeuer A, Ezigbo ED, Fawzy Nazir H, Barco S, Trinchero A, Laubert-Reh D, Strauch K, Wild PS, Lackner KJ, Lämmle B, Rossmann H. c.451dupT in KLKB1 is common in Nigerians, confirming a higher prevalence of severe prekallikrein deficiency in Africans compared to Europeans. J Thromb Haemost. 2021 Jan;19(1):147-152. doi: 10.1111/jth.15137.
• Tanabe S, Fujimura Y, Lämmle B, Kimura T, Isonishi A, Sakai K, Matsumoto M. Stealth thrombosis of brain and kidney in a girl with Upshaw-Schulman syndrome not receiving prophylactic plasma infusions. Int J Hematol. 2020 Nov;112(5):603-604.
• Escher R, Breakey N, Lämmle B. Severe COVID-19 infection associated with endothelial activation. Thromb Res. 2020 Jun;190:62.
• Keller P, von Känel R, Hincapié CA, da Costa BR, Jüni P, Erlanger TE, Andina N, Niederhauser C, Lämmle B, Fontana S. The effects of intravenous iron supplementation on fatigue and general health in non-anemic blood donors with iron deficiency: a randomized placebo-controlled superiority trial. Sci Rep. 2020 Aug 26;10(1):14219.
• Roose E, Schelpe AMB, Tellier E, Sinkovits G, Joly BS, Dekimpe C, Kaplanski G, Le Besnerais M, Mancini I, Falter DT, von Auer C, Feys HB, Reti M, Rossmann H, Vandenbulcke A, Pareyn I, Voorberg J, Greinacher A, Benhamou Y, Deckmyn H, Fijnheer RR, Prohaszka Z, Peyvandi F, Lämmle B, Coppo P, De Meyer S, Veyradier A, Vanhoorelbeke K. Open ADAMTS13, induced by antibodies, is a biomarker for subclinical immune-mediated thrombotic thrombocytopenic purpura. Blood. 2020 Jul 16;136(3):353-361.
• Gresele P, Orsini S, Noris P, Falcinelli E, Alessi MC, Bury L, Borhany M, Santoro C, Glembotsky AC, Cid AR, Tosetto A, De Candia E, Fontana P, Guglielmini G, Pecci A, Bat-Val study Investigators. Validation of the ISTH/SSC bleeding assessment tool for inherited platelet disorders: A communication from the Platelet Physiology SSC. J Thromb Haemost 2020;18(3):732-739.
• Barco S, Sollfrank S, Trinchero A, Adenaeuer A, Abolghasemi H, Conti L, Hauser F, Kremer Hovinga JA, Lackner KJ, Loewecke F, Miloni E, Vazifeh Shiran N, Tomao L, Wuillemin WA, Zieger B, Lämmle B, Rossmann H. Severe Plasma Prekallikrein Deficiency: Clinical Characteristics, Novel KLKB1 Mutations, and Estimated Prevalence. J Thromb Haemost. 2020 Jul;18(7):1598-1617.
• Klingenberg R, Schlager O, Limacher A, Mean M, Vuilleumier N, Beer JH, Staub D, Frauchiger B, Aschwanden M, Lämmle B, Righini M, Egloff M, Osterwalder J, Angelillo-Scherrer A, Kucher N, Banyai M, Rodondi N, von Eckardstein A, Aujesky D, Husmann M, Matter CM. Risk stratification of elderly patients with acute pulmonary embolism. Eur J Clin Invest 2019;49(9):e13154.
• Fujimura Y, Lämmle B, Tanabe S, Sakai K, Kimura T, Kokame K, Miyata T, Takahashi Y, Taniguchi S, Matsumoto M. Patent ductus arteriosus generates neonatal hemolytic jaundice with thrombocytopenia in Upshaw-Schulman syndrome. Blood Adv 2019;3(21):3191-3195.
• van Dorland HA, Taleghani MM, Sakai K, Friedman KD, George JN, Hrachovinova I, Knöbl PN, von Krogh AS, Schneppenheim R, Aebi-Huber I, Bütikofer L, Largiadèr CR, Cermakova Z, Kokame K, Miyata T, Yagi H, Terrell DR, Vesely SK, Matsumoto M, Lämmle B, Fujimura Y, Kremer Hovinga JA; Hereditary TTP Registry. The International Hereditary Thrombotic Thrombocytopenic Purpura Registry: key findings at enrollment until 2017. Haematologica. 2019 Oct;104(10):2107-2115.
• Lauber S, Limacher A, Tritschler T, Stalder O, Méan M, Righini M, Aschwanden M, Beer JH, Frauchiger B, Osterwalder J, Kucher N, Lämmle B, Cornuz J, Angelillo-Scherrer A, Matter CM, Husmann M, Banyai M, Staub D, Mazzolai L, Hugli O, Rodondi N, Aujesky D. Predictors and Outcomes of Recurrent Venous Thromboembolism in Elderly Patients. Am J Med. 2018 Jun;131(6):703.e7-703.e16.
• Jiménez-Alcázar M, Limacher A, Panda R, Méan M, Bitterling J, Peine S, Renné T, Beer JH, Aujesky D, Lämmle B, Fuchs TA. Circulating extracellular DNA is an independent predictor of mortality in elderly patients with venous thromboembolism. PLoS One. 2018 Feb 23;13(2):e0191150.
• Falter T, Herold S, Weyer-Elberich V, Scheiner C, Schmitt V, von Auer C, Messmer X, Wild P, Lackner KJ, Lämmle B, Scharrer I. Relapse Rate in Survivors of Acute Autoimmune Thrombotic Thrombocytopenic Purpura Treated with or without Rituximab. Thromb Haemost 2018;118(10):1743-1751.
• Colucci G, Helsing K, Biasiutti FD, Raio L, Schmid P, Tsakiris DA, Eberle B, Surbek D, Lämmle B, Alberio L. Standardized Management Protocol in Severe Postpartum Hemorrhage: A Single-Center Study. Clin Appl Thromb Hemost 2018;24(6):884-893.
• Seiler E, Limacher A, Mean M, Beer HJ, Osterwalder J, Frauchiger B, Righini M, Aschwanden M, Matter CM, Banyai M, Kucher N, Staub D, Lämmle B, Rodondi N, Squizzato A, Aujesky D. Derivation and validation of a novel bleeding risk score for elderly patients with venous thromboembolism on extended anticoagulation. Thromb Haemost 2017;117(10).
• Méan M, Limacher A, Stalder O, Angelillo-Scherrer A, Alberio L, Fontana P, Beer HJ, Rodondi N, Lämmle B, Aujesky D. Do Factor V Leiden and Prothrombin G20210A Mutations Predict Recurrent Venous Thromboembolism in Older Patients? Am J Med. 2017 Oct;130(10):1220.e17-1220.e22.
• Trinchero A, Schotten S, Lämmle B, Pitton MB. May-Thurner syndrome: missed diagnosis and missed early treatment? Hamostaseologie. 2017 Aug 8;37(3):184-185.
• Jäckel S, Kiouptsi K, Lillich M, Hendrikx T, Khandagale A, Kollar B, Hörmann N, Reiss C, Subramaniam S, Wilms E, Ebner K, Brühl MV, Rausch P, Baines JF, Haberichter S, Lämmle B, Binder CJ, Jurk K, Ruggeri ZM, Massberg S, Walter U, Ruf W, Reinhardt C. Gut microbiota regulate hepatic von Willebrand factor synthesis and arterial thrombus formation via Toll-like receptor-2. Blood. 2017 Jul 27;130(4):542-553.
• Falter T, Schmitt V, Herold S, Weyer V, von Auer C, Wagner S, Hefner G, Beutel M, Lackner K, Lämmle B, Scharrer I. Depression and cognitive deficits as long-term consequences of thrombotic thrombocytopenic purpura. Transfusion. 2017 May;57(5):1152-1162.
• Scully M, Cataland S, Coppo P, de la Rubia J, Friedman KD, Kremer Hovinga J, Lämmle B, Matsumoto M, Pavenski K, Sadler E, Sarode R, Wu H; International Working Group for Thrombotic Thrombocytopenic Purpura. Consensus on the standardization of terminology in thrombotic thrombocytopenic purpura and related thrombotic microangiopathies. J Thromb Haemost. 2017 Feb;15(2):312-322.
• Faller N, Limacher A, Méan M, Righini M, Aschwanden M, Beer JH, Frauchiger B, Osterwalder J, Kucher N, Lämmle B, Cornuz J, Angelillo-Scherrer A, Matter CM, Husmann M, Banyai M, Staub D, Mazzolai L, Hugli O, Rodondi N, Aujesky D. Predictors and Causes of Long-Term Mortality in Elderly Patients with Acute Venous Thromboembolism: A Prospective Cohort Study. Am J Med. 2017 Feb;130(2):198-206.
• Nagler M, Kremer Hovinga JA, Alberio L, Peter-Salonen K, von Tengg-Kobligk H, Lottaz D, Neerman-Arbez M, Lämmle B. Thromboembolism in patients with congenital afibrinogenaemia. Long-term observational data and systematic review. Thromb Haemost. 2016 Sep 27;116(4):722-32.
• Segna D, Méan M, Limacher A, Baumgartner C, Blum MR, Beer JH, Kucher N, Righini M, Matter CM, Frauchiger B, Cornuz J, Aschwanden M, Banyai M, Osterwalder J, Husmann M, Egloff M, Staub D, Lämmle B, Angelillo-Scherrer A, Aujesky D, Rodondi N. Association between thyroid dysfunction and venous thromboembolism in the elderly: a prospective cohort study. J Thromb Haemost. 2016 Apr;14(4):685-94.
• Fan X, Kremer Hovinga JA, Shirotani-Ikejima H, Eura Y, Hirai H, Honda S, Kokame K, Taleghani MM, von Krogh AS, Yoshida Y, Fujimura Y, Lämmle B, Miyata T. Genetic variations in complement factors in patients with congenital thrombotic thrombocytopenic purpura with renal insufficiency. Int J Hematol. 2016 Mar;103(3):283-91.
• Insam C, Méan M, Limacher A, Angelillo-Scherrer A, Aschwanden M, Banyai M, Beer JH, Bounameaux H, Egloff M, Frauchiger B, Husmann M, Kucher N, Lämmle B, Matter C, Osterwalder J, Righini M, Staub D, Rodondi N, Aujesky D. Anticoagulation Management Practices and Outcomes in Elderly Patients with Acute Venous Thromboembolism: A Clinical Research Study. PLoS One. 2016 Feb 23;11(2):e0148348.
• von Krogh AS, Quist-Paulsen P, Waage A, Langseth ØO, Thorstensen K, Brudevold R, Tjønnfjord GE, Largiadèr CR, Lämmle B, Kremer Hovinga JA. High prevalence of hereditary thrombotic thrombocytopenic purpura in central Norway: from clinical observation to evidence. J Thromb Haemost. 2016 Jan;14(1):73-82.
• Kurmann R, Weisstanner C, Kardas P, Hirsch HH, Wiest R, Lämmle B, Furrer H, Du Pasquier R, Bassetti CL, Sturzenegger M, Krestel H. Progressive multifocal leukoencephalopathy in common variable immunodeficiency: mitigated course under mirtazapine and mefloquine. J Neurovirol. 2015 Dec;21(6):694-701.
• von Krogh AS, Kremer Hovinga JA, Romundstad PR, Roten LT, Lämmle B, Waage A, Quist-Paulsen P. ADAMTS13 gene variants and function in women with preeclampsia: a population- based nested case- control study from the HUNT Study. Thromb Res. 2015 Aug;136(2):282-8.
• von Känel R, Margani A, Stauber S, Meyer FA, Demarmels Biasiutti F, Vökt F, Wissmann T, Lämmle B, Lukas PS. Depressive symptoms as a novel risk factor for recurrent venous thromboembolism: a longitudinal observational study in patients referred for thrombophilia investigation. PLoS One. 2015 May 4;10(5):e0125858.
• Jiménez-Alcázar M, Napirei M, Panda R, Köhler EC, Kremer Hovinga JA, Mannherz HG, Peine S, Renné T, Lämmle B, Fuchs TA. Impaired DNase1-mediated degradation of neutrophil extracellular traps is associated with acute thrombotic microangiopathies. J Thromb Haemost. 2015 May;13(5):732-42.
• Edgar CE, Terrell DR, Vesely SK, Wren JD, Dozmorov IM, Niewold TB, Brown M, Zhou F, Frank MB, Merrill JT, Kremer Hovinga JA, Lämmle B, James JA, George JN, Farris AD. Ribosomal and immune transcripts associate with relapse in acquired ADAMTS13-deficient thrombotic thrombocytopenic purpura. PLoS One. 2015 Feb 11;10(2):e0117614.
• Falter T, Kremer Hovinga JA, Lackner K, Füllemann HG, Lämmle B, Scharrer I. Late onset and pregnancy-induced congenital thrombotic thrombocytopenic purpura. Hamostaseologie. 2014;34(3):244-8.
• Stroka D, Keogh A, Vu D, Fort A, Stoffel MH, Kühni-Boghenbor K, Furer C, Banz V, Demarmels Biasiutti F, Lämmle B, Candinas D, Neerman-Arbez M. In vitro rescue of FGA deletion by lentiviral transduction of an afibrinogenemic patient's hepatocytes. J Thromb Haemost. 2014 Nov;12(11):1874-9.
• Jiang Y, McIntosh JJ, Reese JA, Deford CC, Kremer Hovinga JA, Lämmle B, Terrell DR, Vesely SK, Knudtson EJ, George JN. Pregnancy outcomes following recovery from acquired thrombotic thrombocytopenic purpura. Blood. 2014 Mar 13;123(11):1674-80.
• von Krogh AS, Kremer Hovinga JA, Tjønnfjord GE, Ringen IM, Lämmle B, Waage A, Quist-Paulsen P. The impact of congenital thrombotic thrombocytopenic purpura on pregnancy complications. Thromb Haemost. 2014 Jun;111(6):1180-3.
• Colucci G, Alberio L, Demarmels Biasiutti F, Lämmle B. Bilateral periorbital ecchymoses. An often missed sign of amyloid purpura. Hamostaseologie. 2014;34(3):249-52

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Reviews / Editorials / Kommentare

• Cugno M, Onida F, Lämmle B. Complement and transplant-associated thrombotic microangiopathy: Current and future approaches. Hemasphere. 2026 Apr 23;10(4):e70370.
• Cugno M, Lämmle B. The KLF4-CD46 axis: a novel therapeutic target in transplant-associated thrombotic microangiopathy and beyond. Haematologica. 2026 Mar 1;111(3):781-784.
• Laemmle A, Lämmle B. Is congenital thrombotic thrombocytopenic purpura a risk factor for ischemic osteonecrosis of the hip joint (Legg-Calvé-Perthes disease)? Thromb J. 2026 Feb 12;24(1):23.
• Azoulay E, Veyradier A, Cataland S, Joly BS, Knoebl P, Zafrani L, Wendon J, Fakhouri F, Lämmle B, Pavenski K, Biebuyck N, Vanhoorelbeke K, Chaturvedi S, Pishko AM, Donadello K, Scully M, Matsumoto M, Peyvandi F, Mingot-Castellano ME, Zheng XL, Mariotte E, Benhamou Y, Coppo P. Thrombotic thrombocytopenic purpura: early diagnosis and effective treatment in 2025. Intensive Care Med. 2025 Jul;51(7):1225-1239.
• Lämmle B. The third form of thrombotic thrombocytopenic purpura shows up again: what is it, does it even exist, how to find out? Comment on "Acquired thrombotic thrombocytopenic purpura without detectable anti-ADAMTS13 antibodies: a possible underlying autoimmune mechanism" and on "The different faces of thrombotic thrombocytopenic purpura". Haematologica. 2025 Jun 1;110(6):1445-1448.
• Lämmle B, Laemmle A. Vitamin B12 deficiency misdiagnosed as TTP: What can we learn from it? Br J Haematol. 2024 Oct;205(4):1255-1256.
• Uchihara M, Sakai K, Shibata K, Saito K, Lammle B, Matsumoto M. Immune-mediated thrombotic thrombocytopenic purpura with ischaemic cerebral infarction preceding onset of thrombocytopenia and microangiopathic haemolytic anaemia: A case report. Br J Haematol. 2024 Oct;205(4):1649-1652.
• Cataland SR, Coppo P, Scully M, Lämmle B. Thrombotic thrombocytopenic purpura: 100 years of research on Moschcowitz syndrome. Blood. 2024 Sep 12;144(11):1143-1152.
• Halkidis K, Lämmle B, Zheng XL. The history of thrombotic thrombocytopenic purpura research: a narrative review. Ann Blood. 2024 Jun 30;9:16
• Lämmle B. ADAMTS13 recovery in caplacizumab-treated TTP. Blood. 2024 May 2;143(18):1785-1786.
• Lämmle B, Vanhoorelbeke K, Kremer Hovinga JA, Knöbl P. 100 Years of Thrombotic Thrombocytopenic Purpura: A Story of Death and Life. Hamostaseologie. 2024 Feb;44(1):59-73.
• Lämmle B. Mechanisms of ADAMTS13 inhibition in iTTP. Blood. 2023 Jun 15;141(24):2919-2920.
• Lämmle B. A third form of thrombotic thrombocytopenic purpura? Haematologica. 2023 Feb 1;108(2):299-300.
• Lämmle B. A third form of thrombotic thrombocytopenic purpura? Haematologica. 2022 Apr 28.
• Adenaeuer A, Barco S, Trinchero A, Lackner KJ, Lämmle B, Rossmann H. Definite diagnosis of plasma prekallikrein deficiency should not be based exclusively on shortening of the aPTT upon prolonged pre-incubation. Int J Lab Hematol. 2022 Aug;44(4):e179-e180.
• Ten Cate H, Lämmle B. Special Issue: "The Latest Clinical Advances in Thrombocytopenia". J Clin Med. 2021 Aug 5;10(16):3463.
• Lämmle B, Rossmann H. Invited commentary to: ADAMTS13 deficiency is associated with abnormal distribution of von Willebrand factor multimers in patients with COVID-19 by Tiffany Pascreau et al. Letter to the Editors-in-Chief, Thrombosis Research. Thromb Res. 2021 Aug;204:141-142.
• Lämmle B. Endothelial Dysfunction, Atherosclerosis, and Increase of Von Willebrand Factor and Factor VIII: A Randomized Controlled Trial in Swine. Thromb Haemost. 2021 May;121(5):552.
• Sukumar S, Lämmle B, Cataland SR. Thrombotic Thrombocytopenic Purpura: Pathophysiology, Diagnosis, and Management. J Clin Med. 2021 Feb 2;10(3):536.
• Lämmle B. Clinical Problem Solving and Using New Paths in the Laboratory: Learning from Case Studies. Hamostaseologie. 2020 Nov;40(4):414-419.
• Escher R, Breakey N, Lämmle B. Severe COVID-19 infection associated with endothelial activation. Thromb Res 2020;190:62.
• Escher R, Breakey N, Lämmle B. ADAMTS13 activity, von Willebrand factor, factor VIII and D-dimers in COVID-19 inpatients. Thromb Res. 2020 Aug;192:174-175.
• d'Alessandro E, Becker C, Bergmeier W, Bode C, Bourne JH, Brown H, Buller HR, Ten Cate-Hoek AJ, Ten Cate V, van Cauteren YJM, Cheung YFH, Cleuren A, Coenen D, Crijns H, de Simone I, Dolleman SC, Klein CE, Fernandez DI, Granneman L, van THA, Henke P, Henskens YMC, Huang J, Jennings LK, Jooss N, Karel M, van den Kerkhof D, Klok FA, Kremers B, Lämmle B, Leader A, Lundstrom A, Mackman N, Mannucci PM, Maqsood Z, van der Meijden PEJ, van Moorsel M, Moran LA, Morser J, van Mourik M, Navarro S, Neagoe RAI, Olie RH, van Paridon P, Posma J, Provenzale I, Reitsma PH, Scaf B, Schurgers L, Seelig J, Siegbahn A, Siegerink B, Soehnlein O, Soriano EM, Sowa MA, Spronk HMH, Storey RF, Tantiwong C, Veninga A, Wang X, Watson SP, Weitz J, Zeerleder SS, Ten Cate H, Scientific Reviewer C. Thrombo-Inflammation in Cardiovascular Disease: An Expert Consensus Document from the Third Maastricht Consensus Conference on Thrombosis. Thromb Haemost 2020;120(4):538-564.
• Coppo P, Lämmle B. Animal models of thrombotic thrombocytopenic purpura: the tales from zebrafish. Haematologica 2020;105(4):861-863.
• Lämmle B. Hematopoietic Stem Cell Transplantation-Associated Thrombotic Microangiopathy: Pathophysiology and Differentiation from Graft versus Host Disease. Thromb Haemost 2019;119(9):1382.
• Lämmle B. Opana ER-induced thrombotic microangiopathy. Blood. 2017 Feb 16;129(7):808-809.
• Kremer Hovinga JA, Coppo P, Lämmle B, Moake JL, Miyata T, Vanhoorelbeke K. Thrombotic thrombocytopenic purpura. Nat Rev Dis Primers. 2017 Apr 6;3:17020.
• Nagler M, Kremer Hovinga JA, Alberio L, Peter-Salonen K, von Tengg-Kobligk H, Lottaz D, Neerman-Arbez M, Lämmle B. Thromboembolism in patients with congenital afibrinogenaemia. Long-term observational data and systematic review. Thromb Haemost. 2016 Sep 27;116(4):722-32
• Lämmle B. Thrombotic microangiopathy: Caplacizumab accelerates resolution of acute acquired TTP. Nature reviews. Nephrology 12:259-260. 2016.
• Lämmle B. VWF and complement. Blood. 2015 Feb 5;125(6):896-8.
• von Auer C, von Krogh AS, Kremer Hovinga JA, Lämmle B. Current insights into thrombotic microangiopathies: Thrombotic thrombocytopenic purpura and pregnancy. Thromb Res. 2015 Feb;135 Suppl 1:S30-3.
• Lämmle B, Walter U.  Pearls, guidelines & more. Hamostaseologie. 34:199, 2014.

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Buchbeitrag

Bernhard Lämmle and Charis von Auer

Chapter 1 - History of Thrombotic Thrombocytopenic Purpura and the von Willebrand Factor–Cleaving Protease, ADAMTS13.

ADAMTS13 - Biology and Diesease, Editor George M. Rodgers (Springer), ISBN 978-3-319-08716-0